Blood substitutes based on nanobiotechnology.
نویسنده
چکیده
Stimulated by concerns of potential infective agents in donated blood, commercial enterprises have attempted to develop blood substitutes since the 1900s. After several years of development, a few of the many leads are showing promise. In this article, nanobiotechnological approaches that are now in phase III clinical trials are reviewed, followed by a discussion of how important basic knowledge gained is being used to develop new generations of blood substitutes based on nanobiotechnology.
منابع مشابه
5 Nanobiotechnology - based Blood Substitutes and the Cardiovascular Systems in Transfusion Medicine Thomas Ming
Red blood cell membrane contains blood group antigens, and typing and matching are needed before donor blood can be transfused into patients. This results in delays in emergency situations. Donor blood requires storage at 4oC using standard methods and is good for less than 42 d. Red blood cells cannot be sterilized to remove hepatitis viruses, HIV and other potential emerging infective agents....
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In sustained severe ischemia, reperfusion with oxygen carriers may result in ischemia-reperfusion injuries because of the release of damaging oxygen radicals. A nanobiotechnology-based polyhemogloin-calatase-superoxide dismutase can prevent this because the oxygen carrier, polyhemoglobin, is linked to antioxidant enzymes, catalase and superoxide dismutase. However, these antioxidant enzymes com...
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ورودعنوان ژورنال:
- Trends in biotechnology
دوره 24 8 شماره
صفحات -
تاریخ انتشار 2006